Sebastien J Hotte Selected Research

OGX-011

11/2017	Custirsen (OGX-011) combined with cabazitaxel and prednisone versus cabazitaxel and prednisone alone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel (AFFINITY): a randomised, open-label, international, phase 3 trial.
9/2010	Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer.
2/2008	A phase I study of OGX-011, a 2'-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer.

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Sebastien J Hotte Research Topics

Disease

23	Neoplasms (Cancer) 11/2022 - 01/2002
23	Prostatic Neoplasms (Prostate Cancer) 02/2022 - 09/2010
13	Renal Cell Carcinoma (Grawitz Tumor) 11/2022 - 10/2007
7	Fatigue 01/2019 - 02/2008
4	Disease Progression 01/2018 - 01/2010
3	Carcinoma (Carcinomatosis) 01/2022 - 08/2002
3	Neoplasm Metastasis (Metastasis) 12/2021 - 08/2002
3	Kidney Neoplasms (Kidney Cancer) 11/2021 - 10/2007
3	Neutropenia 10/2020 - 10/2013
2	Inflammation (Inflammations) 06/2021 - 02/2015
2	COVID-19 05/2020 - 01/2020
2	Diarrhea 01/2019 - 12/2014
2	Edema (Dropsy) 01/2019 - 02/2016
2	Pain (Aches) 11/2017 - 10/2014
2	Mucositis 03/2017 - 10/2013
2	Breast Neoplasms (Breast Cancer) 01/2016 - 12/2010
2	Squamous Cell Carcinoma of Head and Neck 02/2015 - 06/2008
2	Exanthema (Rash) 12/2014 - 03/2010
2	Lymphoma (Lymphomas) 03/2011 - 05/2009
2	Fever (Fevers) 09/2010 - 02/2008
1	Breast Ductal Carcinoma 12/2020
1	Sarcoma (Soft Tissue Sarcoma) 12/2020
1	Urinary Bladder Neoplasms (Bladder Cancer) 04/2020
1	Infections 01/2020
1	Vomiting 01/2019
1	Hematologic Neoplasms (Hematological Malignancy) 01/2019
1	Proteinuria 01/2019
1	Heart Failure 01/2019
1	Nausea 01/2019
1	Cardiomyopathies (Cardiomyopathy) 01/2019
1	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 12/2018
1	Testicular Neoplasms (Testicular Cancer) 12/2018
1	Asthenia 11/2017
1	Febrile Neutropenia 11/2017
1	Gastroesophageal Reflux (GERD) 03/2017
1	Hand-Foot Syndrome 03/2017
1	Anorexia 02/2016
1	Ovarian Neoplasms (Ovarian Cancer) 01/2016

Drug/Important Bio-Agent (IBA)

9	Docetaxel (Taxotere)FDA Link 02/2022 - 02/2008
7	Pharmaceutical PreparationsIBA 11/2022 - 03/2010
6	Prednisone (Sone)FDA LinkGeneric 10/2018 - 09/2010
6	Sorafenib (BAY 43-9006)FDA Link 08/2012 - 01/2002
3	taxaneIBA 01/2022 - 10/2014
3	enzalutamideIBA 10/2018 - 02/2017
3	cabazitaxel FDA Link 10/2018 - 02/2017
3	abirateroneIBA 01/2018 - 02/2017
3	OGX-011IBA 11/2017 - 02/2008
3	cediranib (AZD2171)IBA 11/2014 - 08/2013
3	Biomarkers (Surrogate Marker)IBA 04/2014 - 07/2009
2	Androgen Receptors (Androgen Receptor)IBA 01/2022 - 08/2012
2	Radium-223IBA 01/2022 - 10/2018
2	AndrogensIBA 12/2021 - 01/2018
2	Sunitinib (Sutent)FDA Link 01/2019 - 03/2017
2	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2019 - 01/2019
2	Cisplatin (Platino)FDA LinkGeneric 12/2018 - 02/2015
2	Abiraterone AcetateIBA 10/2018 - 10/2014
2	temsirolimus FDA Link 02/2016 - 10/2013
2	2,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA 04/2014 - 10/2013
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 04/2014 - 10/2013
2	Decitabine FDA Link 03/2011 - 05/2009
2	Vorinostat FDA Link 03/2011 - 05/2009
2	Lapatinib (GW572016)FDA Link 12/2010 - 09/2007
2	ClusterinIBA 09/2010 - 02/2008
1	trametinibIBA 02/2022
1	durvalumabIBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	PlatinumIBA 01/2022
1	AlbuminsIBA 06/2021
1	Hemoglobins (Hemoglobin)IBA 06/2021
1	3,6-dimethylaminodibenzopyriodonium citrateIBA 10/2020
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 10/2020
1	cabozantinibIBA 01/2019
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019
1	PX-866IBA 01/2019
1	Etoposide (VP 16)FDA LinkGeneric 12/2018
1	Estrogens (Estrogen)FDA Link 12/2018
1	alpha-Fetoproteins (alpha-Fetoprotein)IBA 12/2018
1	Bleomycin (Blenoxane)FDA LinkGeneric 12/2018
1	apatorsenIBA 01/2018
1	Testosterone (Sustanon)FDA Link 01/2018
1	HSP27 Heat-Shock ProteinsIBA 01/2018
1	Mitoxantrone (Novantrone)FDA LinkGeneric 11/2017
1	Opioid Analgesics (Opioids)IBA 11/2017
1	pazopanib FDA Link 03/2017
1	Proteins (Proteins, Gene)FDA Link 02/2017
1	trebananibIBA 02/2016
1	CytokinesIBA 01/2016
1	CDAA (Randox)IBA 01/2016

Therapy/Procedure

19	Therapeutics 11/2022 - 12/2008
18	Castration 02/2022 - 09/2010
12	Drug Therapy (Chemotherapy) 01/2022 - 02/2008
4	Radiotherapy 12/2021 - 08/2002
2	Nephrectomy 11/2021 - 06/2018
2	Neoadjuvant Therapy 12/2020 - 10/2014
2	Cystectomy 04/2020 - 10/2014
1	Immunotherapy 11/2021
1	Surgical Amputation (Amputations) 12/2020
1	Mastectomy (Mammectomy) 12/2020
1	Hand Hygiene 01/2020
1	Adjuvant Chemotherapy 01/2020